A Two-Stage Penalized Logistic Regression Approach to Case-Control Genome-Wide Association Studies
نویسندگان
چکیده
منابع مشابه
A two-stage penalized logistic regression approach to case-control genome-wide association studies
In this talk, we discuss a two-stage penalized logistic regression approach to case-control genome-wide association studies. This approach consists of a screening stage and a selection stage. In the screening stage, main-effect and interaction-effect features are screened by using L1 penalized logistic likelihood in a tournament procedure. In the selection stage, the retained features are ranke...
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Likelihood-based inference of odds ratios in logistic regression models is problematic for small samples. For example, maximum-likelihood estimators may be seriously biased or even non-existent due to separation. Firth proposed a penalized likelihood approach which avoids these problems. However, his approach is based on a prospective sampling design and its application to case-control data has...
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A new type of test is presented for genome-wide association studies using a case-control design. It is referred to as the adaptive two-stage (ATS) analysis, being based on both the Hardy-Weinberg disequilibrium trend test (HWDTT) and the Cochran-Armitage trend test (CATT). The procedure for the ATS is to screen single-nucleotide polymorphisms (SNPs) using the HWDTT in a first stage, and then te...
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ژورنال
عنوان ژورنال: Journal of Probability and Statistics
سال: 2012
ISSN: 1687-952X,1687-9538
DOI: 10.1155/2012/642403